Elizabeth Taylor as Helena Cassadine (1981)
Richard Simmons (2013)
Rick Springfield (2013)
Donna Mills & Morgan Fairchild (2024)
Chandra Wilson as Sydney Val Jean (2024)
John Stamos & Demi Moore (2025)
Peter Stormare (2025)
There have been many different celebrities not appearing as themselves on the ABC soap opera General Hospital.
For a list of cameos and musical guests on General Hospital, please refer to:
Celebrities[]
- Eddie Albert (Jack Boland 1993)
- Richard Dean Anderson (Dr. Jeff Webber 1976-1981)
- Tom Arnold (Billy "Baggs" Boggs 1994)
- Adrienne Barbeau (Suzanne Stanwyck 2010-2011)
- Roseanne Barr (Jennifer Smith 1994)
- Milton Berle (Micky Miller 1981-1982)
- Corbin Bernsen (John Durant 2004-2005)
- Cameron Boyce (Michael "Stone" Cates Jr. GH:NS 2008)
- Yvette Nicole Brown (Unnamed Nurse, 2023) - Attended Epiphany Johnson's funeral after the nurse saved her life
- Tia Carrere (Jade Soong 1985-1987)
- Veronica Cartwright (Sibley Gamble 2019)
- Shaun Cassidy (Dusty Walker 1987)
- Maksim Chmerkovskiy (Anton Ivanov 2013)
- Val Chmerkovskiy (Unnamed Boxer, 2012) - Spoke to Alexis Davis at Volonino's Gym
- Denise Crosby (Dr. Carolyn Webber 2022-23)
- Tyne Daly (Carolyn Beale 1968)
- Sammy Davis, Jr. (Eddie Phillips 1982)
- Bruce Davison (Wilhelm Von Schlagel 2010)
- Kim Delaney (Jackie Templeton 2020-21)
- Morgan Fairchild (Haven De Havilland 2022, 2023, 2024 / Sydney Chase 1996 [her character from The City])
- James Franco (Robert "Franco" Baldwin 2009-2010, GH:NS 2007)
- Guy Gansert (Geoffrey Beckett 2025)
- George Hamilton (Colonel Harland Sanders 2018)
- Mark Hamill (Kent Murray 1972-1973)
- Shirley Jones (Carol McClain 2014)
- Casey Kasem (Jack Collins 1982)
- Walter Koenig (Charlie Turner 1963)
- George Lazenby (Reginald Durban 1982)
- Michael Learned (Shirley Smith 2010)
- Eva Longoria (Brenda Barrett look-alike 2000)
- Meghan Markle (Nurse Jill 2001)
- Ricky Martin (Miguel Morez (1994-1996)
- Debbie Matenopoulos (Michelle, 2024 [Producer at Home & Heart])
- Charles Mesure (Station Chief Jack Brennan, 2023-2025)
- Demi Moore (Jackie Templeton 1982-1984)
- William R. Moses (Dr. Jeff Webber 2022-23)
- Leonard Nimoy (Bernie Smith 1963)
- Ron Reagan (Unnamed Brothel Owner, 1989) - Radio host & son of former President Ronald Reagan, shared scenes with Scott Baldwin
- Carlo Rota (Jenz Sidwell, 2024-present)
- Antonio Sabato, Jr. (John "Jagger" Cates 1992-1995, GH:NS 2008)
- Molly Shannon (Surrogate Mother Candidate, 4/1/1993)
- Rick Springfield (Dr. Noah Drake 1981-1983, 2005-2008, 2012-2013 / Eli Love 2007-2008)
- John Stamos (Blackie Parrish 1982-1984)
- Peter Stormare (The Replacer, 11/7/2025)
- Sally Struthers (Jennifer Smith 2002)
- Gloria Stuart (Catherine Flynn 2002-2003)
- George Takei (Mr. Diem 1985)
- Russ Tamblyn (Nurses Ball Dancer 1997 / Dr. Rose 2000)
- Elizabeth Taylor (Helena Cassadine 1981)
- Ellen Travolta (Gloria Cerullo 1994-1996, 2023, 2024)
- Janine Turner (Laura Templeton 1982)
- Barry Williams (Hannibal 1984)
- Billy Dee Williams (Toussant DuBois 2009, GH:NS 2007-2008)
- Chandra Wilson (Tina Estrada 2014 / Dr. Francine Massey 2018 / Sydney Val Jean 2019, 2023)