- Please note that the rapes listed here did not necessarily take place in the city of Port Charles; rather, this list is of rapes that have either occurred on the show General Hospital, or involved characters from the show.
* denotes that it resulted in a pregnancy
- Jessie Brewer* - by Phil Brewer (1965) (daughter Nancy Brewer died as an infant)
- Audrey Baldwin* - by Tom Baldwin (1969) (son Tom Hardy was born)
- Diana Taylor* - by Phil Brewer (1971) (daughter Martha Taylor died as a child)
- Monica Bard - by Greg Adamson (offscreen; prior to 1976)
- Lesley Faulkner* - by Cameron Faulkner (1976) (baby was miscarried)
- Laura Webber - by David Hamilton (statutory; 1977)
- Laura Webber - by Luke Spencer (1979)
- Franco Baldwin - by Jim Harvey (1979; revealed in 2018)
- Laura Webber* - by Stavros Cassadine (whether it was rape is debatable; 1983) (son Nikolas Cassadine was born)
- Claudia Zacchara-Corinthos* - by Gino Soleito (statutory; offscreen; 1983; revealed 2012) (son Johnny Zacchara was born)
- Todd Manning - by Peter Manning (on OLTL; offscreen; 1984)
- Claudia Zacchara-Corinthos - by Trevor Lansing (statutory; offscreen; c1985)
- Connie Falconeri* - by Joe Scully, Jr. (offscreen; c1986) (son Joey Scully died in 2013)
- Carly Benson - by Dan Roberts (statutory; offscreen; 1989)
- Carla Greco - by Rico Chacone (1990)
- Karen Wexler - by Ray Conway (offscreen; prior to 1992)
- Ryan Chamberlain - by Melanie Chamberlain (offscreen; prior to 1992; revealed in 1995)
- Kevin Collins - by Melanie Chamberlain (offscreen; prior to 1992; revealed in 1995)
- Carol Swift - by Todd Manning (on OLTL; offscreen; c1992)
- Blair Buchanan - by Asa Buchanan (on OLTL; 1992)
- Marty Saybrooke - by Todd Manning, Zach Rosen, & Powell Lord III (on OLTL; 1993)
- Elizabeth Webber - by Tom Baker (1998)
- "Todd Manning"* - by Margaret Cochran (on OLTL; 2005) (son T.J. Manning was born)
- Emily Cassadine - by Connor Bishop (2005)
- Jasper Jacks - by Irina (2007)
- Marty Saybrooke - by "Todd Manning" (on OLTL; consensual at the time but later considered rape; 2008)
- Claudia Zacchara-Corinthos - by Ric Lansing (whether it was rape is debatable; 2009)
- Michael Corinthos - by Carter (offscreen in 2010; shown in flashback 2011)
- Kate Howard - by Johnny Zacchara (whether it was rape is debatable as Connie had DID; 2012)
- Susan Hornsby - by Kyle Sloane (offscreen; prior to 2014)
- Brian - by Jim Harvey (offscreen; prior to 2017)
- Steven Blake - by Jim Harvey (offscreen; prior to 2018)
- Please note that the while the crime itself might not necessarily take place in the city of Port Charles, the trial for said crime did.
- Eddie Weeks (reckless driving causing injury, 1963; guilty)
- Jessie Brewer and Tom Baldwin (murder of John Prentice, 1968; not guilty)
- Audrey March Hardy (murder of Peggy Nelson, 1971; not guilty)
- Diana Taylor (murder of Phil Brewer, 1975; not guilty)
- Anna Devane (attempted murder of Olivia St. John, 1988; acquitted)
- Felicia Jones (attempted murder of Ryan Chamberlain, 1993; found guilty but later acquitted)
- Edward Quartermaine (murder of Bradley Ward, 1994; not guilty)
- Laura Spencer (murder of Damian Smith, 1996; not guilty)
- Monica Quartermaine (sexual harassment of Pierce Dorman, 1997; guilty, later exonerated)
- Tony Jones (kidnapping of Michael Corinthos III, 1998; acquitted)
- Stefan Cassadine (murder of Katherine Bell, 1998; not guilty)
- Tom Baker (blackmail of Emily Quartermaine, 1998; guilty)
- Luke Spencer (murder of Stefan Cassadine, 2000; acquitted)
- Jason Morgan and Brenda Barrett (murder of Luis Alcazar, 2003; not guilty)
- Alexis Davis (murder of Luis Alcazar, 2003; acquitted/self-defense)
- Nikolas Cassadine (murder of Helena Cassadine, 2004; not guilty)
- Sonny Corinthos (murder of A.J. Quartermaine, 2005; not guilty)
- Sam McCall (murder of Diego Alcazar, 2006; dismissed)
- Jason Morgan (murder of Lorenzo Alcazar, 2007; acquitted)
- Monica Quartermaine (reckless driving causing injury, 2008; sent to rehab)
- Johnny Zacchara (murder of Logan Hayes, 2008; not guilty)
- Matt Hunter and Patrick Drake (wrongful death of Brianna Hughes, 2009; charges dropped)
- Sonny Corinthos (murder of Claudia Zacchara-Corinthos, 2010; charges dropped)
- Sonny Corinthos (shooting of an occupied vehicle and attempted murder of Anthony Zacchara, and murder with special circumstances of multiple murders and gang murder of Cole Thornhart and Hope Manning-Thornhart, 2012; not guilty)
- Todd Manning, (kidnapping-switching Danny Morgan and Victor Lord III shortly after birth; 2013; dismissed)
- A.J. Quartermaine (murder of Connie Falconeri, 2013; not guilty)
- Julian Jerome (murder of Duke Lavery and Carlos Rivera, attempted murder of Alexis Davis, 2016; not guilty)
- Dr. David Bensch (sexual harassment of Kiki Jerome, 2018; guilty, fired from GH)
- Nelle Benson, (offscreen murder of her fiance, Zachary Grant, 2018; plead no contest, given the maximum sentence and remanded to Pentonville)
- Sam McCall (murder of Hank Archer, 2019; not guilty for first degree murder, guilty for involuntary manslaughter; sentenced to two years at Pentonville, released early on parole due to good behavior on Christmas Eve 2019)
- Brad Cooper, (kidnapping-switching Wiley Cooper-Jones and Wiley Quartermaine-Corinthos shortly after birth; 2020; guilty, remanded to Pentonville Penitentiary)
- Nelle Benson-Jerome, (kidnapping-switching Wiley Cooper-Jones and Wiley Quartermaine-Corinthos shortly after birth; 2020; acquitted due to lack of evidence)
- Marcus Taggert, (framing a guilty Cyrus Renault with manufactured evidence of his drug trafficking; 2021; not guilty plea and let out on bail)
- Alexis Davis, (assault after accidentally stabbing Dante Falconeri with a syringe of lidocaine while aiming for Franco Baldwin; 2021; guilty plea, sentenced three years at Pentonville)
- Jason Morgan, (falsely accused of Franco Baldwin's murder; 2021; bail denied and remanded to Pentonville to await trial; exonerated on Jun 4, 2021)
- Spencer Cassadine, (terrorizing & stalking Ava Jerome); released on bail on Oct 22, 2021; changed his plea to guilty on Dec 23, 2021; sentenced to 30 days in Spring Ridge Prison, 500 hours of community service and making restitution to Ava as a result; released from Spring Ridge on Mar 23, 2022)
- Trina Robinson, (Cyber sexual harassment & 2nd degree unlawful surveillance - falsely accused of filming Cameron Webber and Josslyn Jacks having sex, then releasing it to the public; released without bond pending a trial on Apr 1, 2022; exonerated & charges dropped due to witness testimony on August 16, 2022; which led to --
- Esme Prince, (Cyber sexual harassment & 2nd degree unlawful surveillance, framing of Trina Robinson, drugging of Trina Robinson and Oz Haggerty - filmed Cameron Webber and Josslyn Jacks having sex, then releasing it to the public; remanded to Spring Ridge Prison (January 17-March, 2023) for trial date; charges put on hold due to mental capacity)