In 2021, the role of Drew was recast with former All My Children alum, Cameron Mathison, who's voice was first heard as Drew on August 16, 2021. Mathison made his first appearance as Drew on August 17, 2021.
The role of Margaux Dawson was originated by actress, Elizabeth Hendrickson from May 29, 2018 to June 18, 2019.
Billy Miller and Elizabeth Hendrickson were a popular pairing (Billy Abbott and Chloe Mitchell) on "The Young and the Restless" and GH tried to recreate it by pairing Drew and Margaux.
On July 17, 2018, Drew Cain was outside of a baseball game and someone had squirted mustard onto his shirt. District Attorney, Margaux Dawson apologized to Drew for accidentally getting mustard on his shirt and tried to clean it off with water, but Drew stopped her and said he got water. Margaux offered to pay for his dry cleaning but Drew didn't want her to worry about it. They bonded over baseball.
On July 23, Margaux went to see Drew at the restaurant in the Metro Court and gave him a hat as a peace offering. Drew accepted it but said that he wasn't aware that they were fighting. They then talked about his upcoming high school reunion and Drew revealed that he has no memories of his life prior to 2014, which intrigued Margaux.
On August 24, they went out on a date at the Floating Rib where they ran into Carly and Jason, Carly accused her of using Drew to get to Jason to which Margaux rebuffed and claimed otherwise. Later when Drew took Margaux back to her room, she excused herself to change her blouse, and when she returned she saw Drew holding a flash drive. She panicked and claimed it contains evidence for a case, but he guesses that she's lying. She shows him the photos on the flash drive of her as a kid in her computer. He apologizes. She wonders if he got himself invited in just to search her suite. After a back and forth argument, Drew decides to leave but as he's about leave, Margaux stops him and they kiss. Later when he leaves, she takes a flash drive labelled Anamnesis Project out of her vault.
On December 10, Margaux gives Drew the flash drive containing his memories in an attempt to make peace with him. At first he doesn't want to take it, but Margaux forces him to take it.