Full Siblings are rare on Soap Opera's and especially on General Hospital.
- Dr. Alan Quartermaine (deceased) and Tracy Quartermaine are the children of the late wealthy businessman, Edward Quartermaine and his late wife, Lila Morgan. They have two paternal half-brothers, the late Reverend Dr. Bradley Ward (through an affair with the late Mary Mae Ward) and the late Jimmy Lee Holt (through an affair with Beatrice LeSeur).
- Pat Spencer, Luke Spencer, and Bobbie Spencer (all deceased) are the children of the late Tim Spencer and his late wife, Lena Eckert.
- Lindsey Devane (deceased) and her twin sisters, Special Agent Anna Devane and Dr. Alex Devane, are the daughters of the late Thomas Devane and an unknown woman. They have one paternal half-brother, Gabriel Devane.
- Director Frisco Jones and Dr. Tony Jones (deceased) are the sons of the late Andrew Jones and the late Cindy Jones.
- Prince Stavros Cassadine and Prince Stefan Cassadine (both deceased) were the sons of the late Prince Mikkos Cassadine and his late wife, supervillain Helena Romanov. They had a maternal half-sister, the late Irina Cassadine, and a maternal half-brother, Valentin Cassadine (through an affair with Dr. Victor Cassadine). They have two paternal half-sisters, Alexis Davis and the late Princess Kristina Cassadine (through an affair with the late Kristin Bergman).
- Alexis Davis (born Princess Natasha Cassadine) and Princess Kristina Cassadine (deceased) are the daughters of the late Prince Mikkos Cassadine and his late mistress, opera singer Kristin Bergman. Stavros and Stefan Cassadine are their paternal half-brothers.
- Twins Dr. Kevin Collins and the late serial killer Dr. Ryan Chamberlain are the sons of Victor Collins and his late ex-wife, Melanie Chamberlain.
- Jerry Jacks and Jasper Jacks are the sons of the late John Jacks and his late wife, Lady Jane Jacks.
- Agent John Cates, Gina Cates, and the late Stone Cates are the children of the late Lewis and Sophia Cates.
- Evan Jerome, Sr., Julian Jerome, and Olivia Jerome (all deceased) are the children of the late mob boss Victor Jerome and an unknown woman. They have two paternal half-siblings, Dino Antonelli (deceased) (through an affair with the late Dimitra Antonelli) and Ava Jerome (through an affair with Delia Ryan).
- Twins Jason Morgan and Chief Drew Cain are the sons of the late Dr. Alan Quartermaine and his late mistress, Susan Moore. They have one paternal half-brother, the late A.J. Quartermaine (with their adoptive mother Dr. Monica Bard), and three adoptive siblings, paternal-half Skye Chandler-Quartermaine, the late maternal-half Dawn Winthrop, and the late full Dr. Emily Quartermaine.
- Dr. Sarah Webber and Nurse Elizabeth Webber are the daughters of Dr. Jeff Webber and his wife, Carolyn Webber. They have two paternal half-siblings, Dr. Steve Webber (with Heather Webber (née Grant) and Hayden Barnes (through an affair with the late Naomi Dreyfus).
- Twins Dr. Emily Quartermaine (deceased) and Rebecca Shaw are the daughters of the late Hank Bowen and his late wife, Paige Bowen, although they were adopted by two completely different and separate families. Emily was taken in by adoptive parents Dr. Alan and Dr. Monica Quartermaine while Rebecca was taken in by adoptive parents William and Nancy Shaw.
- Dr. Britt Westbourne and Det. Nathan West (both deceased) are the children of the late supervillain Cesar Faison and Dr. Liesl Obrecht. They have a paternal-half brother, the late villain Peter August (through a fling with the late Alex Devane).
- Lucky Spencer and Lulu Spencer are the children of legendary supercouple Luke Spencer (deceased) and Mayor Laura Collins (née Webber, formerly Spencer). They have one maternal half-brother, Prince Nikolas Cassadine (with the late Prince Stavros Cassadine) (deceased). They have one paternal half-brother, Ethan Lovett (through an affair with Holly Sutton).
- Maxie Jones and the late Georgie Jones are the daughters of supercouple Director Frisco Jones and Felicia Cummings. They have one stepbrother, Cody Bell, through their mother’s marriage to Mac Scorpio.
- Morgan Corinthos (deceased) and Donna Corinthos are the children of supercouple Sonny Corinthos and Carly Spencer. They have one paternal half-brother, Dante Falconeri (with Olivia Falconeri), and one maternal half-brother Michael Corinthos (with the late A.J. Quartermaine, adopted by Sonny). They have two paternal half-sisters, Kristina Corinthos-Davis (with Alexis Davis) and Avery Jerome-Corinthos (with Ava Jerome), as well as one maternal half-sister, Josslyn Jacks (with Jasper Jacks). Donna was born several years after her brother Morgan’s presumed death, and has never met her only full sibling.
- Emma Scorpio-Drake and Noah Scorpio-Drake are the children of Dr. Patrick Drake and his wife, Dr. Robin Scorpio. They have one paternal half-brother, the late Gabriel Santiago (with the late Nurse Sabrina Santiago). They were the first full siblings born on General Hospital in over 20 years.
- Kiefer Bauer and Kendra Bauer (both deceased) are the full siblings of the late Warren Bauer and his wife, Melinda Bauer.
- Cyrus Renault and Martin Grey are the sons of the late Professor Gordon Grey and his wife, Florence Grey. They have one paternal half-sister, Laura Webber (through an affair with Dr. Lesley Sullivan).
- The late Nelle Benson and Willow Tait are the fraternal twin daughters of the late Dr. Silas Clay and his ex-wife, Nina Reeves. They have one paternal half-sister, the late Kiki Jerome (through an affair with Ava Jerome).
Possible Full Siblings