There are a variety of holidays and other special events that are celebrated on General Hospital.
On Valentine's Day 2022, Port Charles ran on an unofficial theme of "love stinks", due to all the loses in the last year.
Fourth of July
Citizens enjoy watching the fireworks in Rice Park.
- In December 2019, a GH version of A Christmas Carol with Hamilton Finn as Ebenezer Scrooge was shown.
New Year's Eve
On New Year's Eve 2015, Leo Falconeri was conceived just after midnight at the Metro Court Hotel. Julian Jerome and Olivia Falconeri kissed at midnight because they were alone and ended up in bed together.
- On April 17, 2002, Audrey Hardy's 10,000th day working at GH is celebrated to mark the 10,000th episode of the show. Many flashbacks were featured and GH's first patient Angie Costello returned.
- For the 50th anniversary in April 2013, the ghosts of Emily Quartermaine, Alan, and Rick Webber appeared.
- For the 51st anniversary in April 2014, Sonny Corinthos talked to three actresses who played Carly Benson (three versions of Carly) in the GH chapel.
- For the 52nd anniversary in April 2015, Luke Spencer flashed back to his childhood on April 1, 1963 when he accidentally killed his parents.
- On June 17, 2022, the 15,000th episode will air, focusing on Laura Collins and will feature the majority of GH's current characters.
- The Floating Rib occasionally had karaoke nights. In September 2019, they had a Drag Bingo night.
- In December 2015, GH had a Nutcracker Gala as a fundraiser for Toys for Tots.
- In 2021, Charlie's Pub has Trivia Nights.
- On May 13, 2022, Port Charles Elementary has a fair at Rice Plaza.
- "All About Ava" (01/17/2018): Ava has a nightmare as she is about to have her face repaired.
- "Vote" (11/02/2020): Josslyn Jacks and Trina Robinson go back 100 years and learn about Port Charles' voting history.
- "What If" (11/12/2018): Sonny imagines what his life would be like if he didn’t live a life of crime.