Sam discovers she is pregnant while she is dating Sonny Corinthos. However, she is unsure of who the father is, because she also slept with Jasper Jacks the night of Port Charles hotel fire.
During the pregnancy, Sonny breaks up with Sam, and returns to his wife, Carly, and their family. Jason Morgan offers to help raise the little girl after learning that Sam is pregnant. Jason and Sam plan to marry before the little girl arrives but don't.
When Kristina Corinthos-Davis was suffering from leukemia and required a bone marrow transplant, the little girl was found to be a match, and doctors said that Kristina would need the stem cells from the little girl's umbilical cord. Sam needed to induce an early labor to give the stem cells, but she refused, afraid for her daughter's life. However, Alexis Davis, Kristina's mother, confronted Sam, and yelled at her until she agrees to induce labor.
Sam, though, collapsed during the confrontation from abruptio placentae, where the placenta suddenly detached, cutting off the little girl's blood and oxygen. Doctors immediately performed a C-section on Sam, but her daughter was stillborn. Sonny allows them to take the little girl's umbilical cord for the stem cells needed to save Kristina's life.
On her headstone, it says says "Baby Girl McCall." She died before her parents made her name official. The name "Lila" had been decided on after Jason’s grandmother, Lila Quartermaine, died while Sam was pregnant. Sam asked Jason if she could name her daughter Lila in honor of her, especially since Lila's maiden name was Morgan; Sam said there'd be another Lila Morgan, and Jason told her that his grandmother would love it, if they gave the baby her name.
Jason, her surrogate father, was the only person out of all of Lila's family members that ever got to see or hold her before she was buried. He described her as having dark, curly hair and a face shaped like Sam's.
Jason also planned her memorial service, since Sam was in no position to do it herself. After the funeral, Jason and Sam grieved for Lila together and helped each other heal.
On September 20, 2005, an amnesiac Jason ended up at Lila's tombstone and then Sam showed up.
In 2006, Mother Sam had a nightmare that Manny kidnapped alive Lila but also had dream that she was with her adopted brother Danny was taken care of her daughter Lila in heaven.
On November 8, 2006, Mother Sam visited her daughter's gravesite on what would've been her second birthday.
Sam and Jason got into a fight when he gave her Lila pink blanket intended for Lila if she was still alive results in Sam and Jason break up.
Lucky mention Sam’s daughter Lila as a “miscarriage”when they had a fight about Liz and Jason son Jake Spencer being kidnapped her mother Sam.
On June 25, 2007, Mother Sam visited her daughter's gravesite and talked to her about Jason having a son Jake with Liz.
During Lila younger brother Danny birth her mother Sam mentioned Lila birth on June 1,2012.
2012,When younger Danny was presumed dead Lila was mentioned by mother Sam in the hospital after fighting with Jason over Danny “death”.
2017,When her mother Sam was pregnant with her younger sister Scout Dr.Lee mention Sam had a “miscarriage“in the past referring to stillborn Lila.
On November 10, 2017, Jason tells Scout Cain about her older sister.
On August 21, 2018, the day of Michael's "son's" funeral, Jason and Sam remember about Lila. In the fall of 2018, it will be 14 years since Lila's death.
Sam also told Jason "I would not have survived losing Lila without you, you know that; I would’ve given up if I didn’t have you to hold on too."
As of November 8, 2020 Lila McCall would've been 16 years old when hit her 16th death anniversary.