Laura began dating Scott Baldwin and caused a bit of a stir by asking Rick's former lover, Dr. Monica Quartermaine for birth control pills so that she could sleep with him. While she was dating Scott, an old "friend" of Rick's named David Hamilton was busy trying to seduce Lesley in revenge as David's late wife had apparently always been in love with Rick.
When David's seduction of Lesley failed, David decided that Laura would serve his purposes just as well and began befriending her. Laura became smitten with the older man and the two embarked on an affair. When David's schemes to defraud General Hospital came to light he made plans to flee Port Charles. Laura wanted to go with him but David refused and revealed to Laura that he'd only been using her to get revenge on her parents. In a fit of anger, Laura pushed David and he fell and hit his head on the hearth and died. Lesley arrived on the scene and quickly got her daughter away from the scene of the crime.
When Laura couldn't remember what happened, Lesley took the blame and claimed to the police that she had killed David in self-defense when he had tried to rape her. The police did not believe Lesley's story and soon Lesley found herself on trial for murder. When Laura finally remembered that she, not Lesley, had killed David, she ran away to New York City. Scotty and his best friend Bryan Phillips found her there and brought her home, where Laura finally confessed to the crime. Since the crime was accidental, Laura was given six months probation.
During Laura's troubles with David Hamilton, Scotty had started sleeping with Bobbie Spencer and Bobbie was now stunned to find herself cast aside in favor of Laura. Bobbie began scheming to break up Scott and Laura and brought her brother Luke Spencer into her schemes. When trying to get Laura to break her probation and sent to reform school didn't work, Bobbie tried faking a pregnancy in order to get Scott to marry her. However, when that didn't work, Bobbie tried to make Laura think she had slept with Scott again. This time, her plan worked but had the unintended effect of making Laura rush off and crash her car. Luke was upset at this turn of events and ordered Bobbie to stop her scheming. Bobbie, herself filled with guilt and remorse, complied and stood back as Scott and Laura were reunited. With permission from her parents, she marries Scott Baldwin on July 6th, 1979. She spends a lot of money on law books for Scott and to get out of debt she asks Luke Spencer for a job at the campus disco. Luke eventually falls deeply in love with her. On the night he finally confesses his love for her, thinking he is going to die, he loses control and rapes her on the floor of the campus disco.
Laura refuses to name her rapist and Laura somehow forgives him in a letter. Scott finds the letter and punches Luke just before his wedding to Jennifer Smith. Laura saves his life after he falls off the yacht. They then run off together and fall in love in the process. Upon returning to Port Charles, Laura admits she was married after being hounded by reporters, breaking Luke's heart. She goes on the search for Scott who had also run off but keeps bumping into Luke. They later admit they can't live without each other.
When they get back home, Laura files for a divorce with Scotty so she and Luke can plan their wedding.
In the 2000s, Laura was shocked to learn that Felicia and Luke had slept together the night Stefan disappeared and she tries to drown her pain in alcohol. Scott then comes to take her home.
Laura moves on by obtaining Deception Cosmetics from Scotty with the funds of Sonny Corinthos. In June 2001, Luke and Laura tearfully remember their past together as they sign their divorce papers. They agree it is time to put the past to rest but they can't stay out of each other's minds. Stavros returns after being cryogenically frozen by Helena for several years. He constantly stalks her, scaring her to death when he showed himself to her in a mirror on a dark night. Laura leaves town again with her mother and daughter for the summer. She returns to find that Luke had mysteriously vanished. He eventually surfaces suffering from an illness that causes him to cycle his past. She helps Luke get his memory back, puts a pause on her relationship with Scott, and helps Stefan escape jail after he is arrested for Chloe Morgan's murder.
When Luke collapses, Laura pleads with his unconscious body not to leave her and confesses her love for him. Just as Luke starts to recover, Laura and Nikolas go to confront Helena in her underground lab. Right before the lab shuts down, Luke slides under the door, and is embraced by Laura stating that everyone could use a happy ending. Soon afterward, Scott asks Laura to marry him all over again, fearing that she will leave him for Luke. She ponders the question for awhile and is unhappy when Luke found out about it when Lulu blurts it out at Thanksgiving dinner. Though he is hurt, Luke tells her to marry Scotty, but Laura ends up turning Scotty down.
When Laura realized her recent dreams were actually memories, Luke agreed to help Laura unravel her past. As Laura began to remember more about what happened in the garage attic, she also realized that Scotty knew what had happened but wouldn't tell her. Laura eventually remembered the face of the woman involved and had Elizabeth sketch it for her. Rick seemed uncomfortable when she showed it to him and begged Laura to leave the past alone. Lesley confirmed that the picture was of a nurse who used to work at GH. With the identity of the nurse revealed, Luke tried tracking the nurse down but she seemed to have fallen off the face of the earth.
Meanwhile, with the wedding fast approaching, Laura's grasp on reality began slipping as more and more flashbacks appeared to indicate that Rick might have killed Theresa. Things reached a climax when Laura returned to the attic on the eve of her wedding. Rick soon joined her there. As they talked Laura became more and more convinced that Rick had killed his lover in the attic. Rick denied it but he refused to tell her what happened and instead slowly approached her with a syringe. Believing Rick murdered Theresa, Laura became frantic when he tried to inject her with an unknown substance. Fearing for her life, she grabbed the first object she could find, a heavy candlestick, and hit him over the head, killing Rick. Luke arrived but it was too late to save Rick. Realizing that Laura was in deep trouble, Luke tried to get her out of the attic but Laura was not cooperative. She was covered in blood and suffering a complete psychotic breakdown. Scott Baldwin soon joined them and realizing he had no choice, he told Luke what had happened all those years ago. A teenaged Laura had surprised Rick and his lover, Theresa who were in the attic. Theresa, who was obsessed with Rick, wanted Rick to leave Lesley but he refused. Laura walked in on the heated moment and the shock of seeing her beloved stepfather in a compromising position with a volatile woman made Laura act on instinct. She grabbed a camera and hit Theresa over the head, killing her.
Rick, fearing what would happen to Laura and seeing how traumatized she was by what she had done, quickly sedated her with a drug that also helped cloud recent memories. He then called Scotty to help him with the body. Rick and Scotty buried Theresa in the backyard to protect Laura from being charged and convicted of murder. When Luke and Laura didn't show up for their wedding the next day, Lesley guessed that they had eloped. But when Lucky and Nikolas found Rick Webber dead in the attic, they feared that Luke had killed him for some unknown reason. Even though Nikolas and Lucky tried to make it look like Rick had died in a drunk-driving accident, Scott didn't buy it and believed Luke was responsible.
Luke realized that Laura was losing her grip on reality, but played along with her wedding fantasy and shared touching vows with her. Laura grew hysterical again and as Luke was calming her, Scott and Mac Scorpio showed up. Luke was arrested for Rick's murder and Laura was taken for psychiatric evaluation. At the hospital, Scott questioned Laura and he secretly taped her confessing to killing Rick. Luke proclaimed his innocence at first, but when Scott played him the tape of Laura's confession, Luke changed to proclaiming his guilt in Rick's murder.
In 2006, Lulu started digging around and discovered that Scott Baldwin had actually killed Rick Webber.
In October 2008, overhearing a lethal injection threat issued by Scott Baldwin to her daughter, Lulu Spencer, Laura reawakens to protect Lulu. Scott kidnaps Laura, taking her to California to relive their honeymoon in hopes of rekindling their relationship. While in California, Laura continues to tell Scott that she has come along with him only so he will not prosecute Lulu. She lets Scott know that although she cares about him, she will always love Luke Spencer and reminds him that she is married to Luke. Scott eventually tells Laura that Luke has been married to Tracy Quartermaine for the last three years and that Luke had staged Laura's wedding to him, two years before.
Luke, after finding out at Shadybrook that Scott has kidnapped Laura, catches up with Scott and Laura in California. Seeing Scott and Laura in a car, Luke steals a taxi and pursues the couple in a high speed chase. On November 3, Scott and Laura's car crashes along the edge of a cliff. During a rescue attempt, Luke drags Scott from the car, but in his attempt to save Laura, the car goes over the cliff with him and Laura in it. Although bruised, Luke and Laura live through the crash, but find that they are in the wilderness. They eventually find a cabin, where they discuss Luke's marriage to Tracy and the outlook of their own relationship. On November 10, the Spencer children find their parents safe at the cabin. They all reunite with Scott and Tracy at a hotel in California and decide to return to Port Charles. After catching up with her children's lives and dealing with the fact that Luke has married Tracy and moved on with his life, Laura decides she also needs to move on with her life. She announces to her family on November 12 her intention to go to France, where the clinic for her LS-49 treatment is located. Unbeknownst to Laura, Scott Baldwin is on the plane; as it lifts off, he is seen behind a curtain looking at her.
In 2013, Laura returns to The Haunted Star, encountering a bewildered Luke. Laura reveals that she is getting married to Scott again. Scott is really controlling and tells Laura to not do things.
Laura is hesitant about marrying Scotty Baldwin, but after kissing Luke she realizes that she needs to move on. She decides to move forward with the wedding to this month. Her mother Lesley Webber and her grandson Spencer Cassadine arrives at Wyndemere because her son Nikolas wanted them to visit. Scotty demands to Luke that he will not be present at the wedding and Nikolas offers Wyndemere for the wedding. Mayor Janice Lomax was initially stated as the officiant of the wedding, but Laura's mother Lesley Webber steps in to officiate when Mayor Lomax can't make it.
While at the hospital, Laura finally connects with Scott and he tells her that divorce is the best thing for them because she hangs around Luke too much. Laura eventually tearfully agrees with it.