The role of Samantha McCall was originated by former Baywatch star and Playboy's April 1997 Playmate of the Month, actress Kelly Monaco, who debuted on October 1, 2003.
In 2006, Monaco was nominated for a Daytime Emmy Award in the Outstanding Lead Actress category for her portrayal of Sam.
When they first met in May 2013, they didn't like each other at all (more on her side).
The couple went to the 2014 Nurses' Ball together.
Sam ended their relationship in July 2014 because of Silas' then wife, Nina.
In 2015, Silas was murdered by Madeline Reeves.
It's revealed on April 9, 2020 that Nelle Benson is in fact Silas’s long-missing daughter with Nina. Previously, Sam and Nelle had been cellmates at Pentonville - and Nelle's son and Sam's godson was Wiley Quartermaine-Corinthos.
It's revealed on April 8, 2022 that Willow Tait is in fact Silas' long-missing daughter with Nina and also Nelle's fraternal twin sister. Previously, Sam and Willow had been fellow Dawn of Day Cult members and Willow's son, the late Wiley Cooper-Jones, had been switched with Sam's godson, Wiley Quartermaine-Corinthos.
Silas and Sam first met when Sam went to New York to look for Morgan. Silas was working at a hospital there and when Sam first saw him she thought that he was his brother, Stephen who had recently terrorized Sam and people close to her. Silas had a hard time getting her to believe that he actually wasn't Stephen.When Sam finally believed him she told him about his nephew, Rafe who was then her foster son and how his parents had died. A shocked Silas responded coldly. Sam left the hospital shortly thereafter to continue looking for Morgan. Silas eventually shows put ing Port Charles, to which Sam and Rafe react negatively too. Silas also eventually gets custody of Rafe.