The role of Helena Cassadine was originated by Elizabeth Taylor in November 1981 for a short run. In 1996, the role was recast with Dimitra Arliss.
In 1997, the role was recast with Constance Towers, who's held the role the longest. Towers portrayed Helena on and off from 1997 until the character's death in 2015, but has made several guest appearances in 2016, 2017, 2019 and 2020.
On New Year's Eve 2019 (shown on January 6, 2020), Nikolas Cassadine crashed Valentin Cassadine and Nina Reeves' wedding and revealed himself to be alive after supposedly being killed by Valentin in 2016. After revealing that Mikkos Cassadine had a codicil which disinherits Valentin and his daughter, Charlotte while returning everything back to Nikolas and his son, Spencer, Nikolas revealed that Valentin isn't Mikkos' son - he's actually Helena's son. Valentin didn't believe Nikolas at first, but Nikolas successfully took back Wyndemere and everything Valentin had stolen back in 2016.
On February 12, Valentin got the results of a DNA test he'd done and was stunned and devastated to learn that he's not a Cassadine.
On September 2, 2021, Victor Cassadine was revealed to be alive after he was thought to have been killed in 2014.
On October 7, 2021, it was revealed that Victor is Valentin's father, which meant that Valentin and Charlotte are true Cassadines after all.